Inflammatory Sleep Disruption: How Chronic Inflammation Fragments Sleep and How to Recognize It
Overview: Inflammatory sleep disruption occurs when persistent, low-level immune activation — elevated cytokines, overactive inflammatory pathways, and immune cells in a sustained activated state — can interfere with the biological processes that produce and maintain sleep. Five mechanisms appear to contribute to it: Cytokine overload — chronic elevation of IL-6, TNF-α, and IL-1β is associated […]