Does Growth Hormone Affect Dementia Risk?
How to Support Growth Hormone After Midlife Without Taking Hormones
Is dietary cholesterol required for good human health?
A deep-dive on how dietary cholesterol might or might not affect your LDL-C
Cholesterol is one of the body’s most tightly regulated and energetically expensive molecules; however, it is still widely portrayed as something to restrict or minimize.
Every nucleated cell can synthesize it, and several organs use substantial metabolic resources for its local production. In some tissues, most notably the brain, dietary cholesterol does not materially influence cholesterol content under normal physiological conditions because lipoprotein-bound cholesterol does not cross the intact blood–brain barrier.
This raises a central biological question: if cholesterol can simply be obtained from food, why did evolution invest in such an elaborate and tightly regulated system to manufacture it internally?
The answer lies in the indispensable structural, metabolic, and signalling roles of cholesterol and the biological necessity of local, on-demand synthesis.
Cholesterol is not only useful but also essential for multicellular life.
Is dietary cholesterol required for good human health? Read Post »
The Underrated Biomarker That Predicts Stroke & Dementia Risk
It’s not HRV, glucose, or inflammation. But it predicts your risk of stroke, dementia, and kidney decline decades before symptoms.
When was the last time you checked your blood pressure—without being told to?
Most people only learn their numbers when they’re already high.
But here’s what often gets missed:
Blood pressure is one of the strongest, easiest-to-monitor predictors of long-term health.
And ~50% of all U.S. adults already fall above the “normal” range.
That’s not just a cardiovascular issue. It’s a brain, kidney, and aging issue.
Let’s unpack why—plus the simple protocol I’ve followed to keep mine at 101/66 for 20+ years.
No meds. No salt restriction.
The Underrated Biomarker That Predicts Stroke & Dementia Risk Read Post »
Vitamin C, calcium, iron & D3: they can never hurt… right?
+ 3 categories of supplements I avoid 100% of the time.
Vitamin C, calcium, iron & D3: they can never hurt… right? Read Post »
Kidney Stone Prevention (beyond hydration & avoiding spinach)
A lot of Longevity Vault members have asked me over the years: “If I just drink more water and avoid spinach, am I safe from kidney stones?”Or: “Kidney stones run in my family—does that mean I’m stuck with them?” Short answer: those things matter. Longer answer: they only touch a small part of the problem. Most kidney stones—70-80%—are calcium oxalate. So if you’re thinking about prevention, oxalate is the main variable. That sets up the more useful question: Is “water + avoiding high-oxalate…
Kidney Stone Prevention (beyond hydration & avoiding spinach) Read Post »
Vitamin B12 and Fertility: How It Impacts Testosterone and Sperm Count
Testosterone and sperm aren’t just fertility metrics—they’re early biomarkers of how your body is aging. This article breaks down the overlooked role of vitamin B12 in male hormone health, sperm motility, and DNA integrity. Backed by human studies, mechanistic data, and actionable testing tips, it makes the case for using B12 status as an early signal for biological decline.
Vitamin B12 and Fertility: How It Impacts Testosterone and Sperm Count Read Post »
B12 Blood Tests Explained: What to Ask Your Doctor—and What the Results Actually Mean
A standard vitamin B12 blood test often misses the earliest signs of decline. If you’re optimizing for cognitive function, energy, and longevity, you need deeper markers. This guide breaks down the 3 tests that reveal what total B12 can’t.
B12 Blood Tests Explained: What to Ask Your Doctor—and What the Results Actually Mean Read Post »
Vitamin B12 and Brain Fog: What Blood Tests Miss About Early Cognitive Decline
B12 brain fog might seem harmless—but new research suggests it could be an early warning sign of cognitive decline. Here’s what to watch for before it’s too late.
Vitamin B12 and Brain Fog: What Blood Tests Miss About Early Cognitive Decline Read Post »
How to Use the Interleukin 6 Test for Early Inflammation Detection and Longevity
Most inflammation tests only catch the aftermath. The interleukin 6 test can detect trouble earlier—before symptoms or CRP even rise. Learn how to use IL-6 testing for smarter, longevity-focused decisions.
How to Use the Interleukin 6 Test for Early Inflammation Detection and Longevity Read Post »
Interleukin-6 and Longevity: The Missing Signal Behind Aging and Brain Health
IL-6 is an early driver of inflammation, aging, and brain decline—often years before symptoms. Learn why IL-6 testing matters for longevity and how it offers deeper insight than CRP alone.
Interleukin-6 and Longevity: The Missing Signal Behind Aging and Brain Health Read Post »